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. 2021 Jun 4;23:63. doi: 10.1186/s13058-021-01416-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Residual metastases exhibit cellular dormancy. a–d Lung metastasis in MTB;TetO-HER2/neu;TTC;rYFP mouse on doxycycline (top) or residual lung metastasis following doxycycline withdrawal (bottom). a H&E-stained sections (left) or YFP fluorescence microscopy (right). b IF for Ki67 (left) or Ki67, YFP and Hoechst 33258 (right). c IF for YFP, Hoechst 33258, and CD31 (left), fibronectin (center) or collagen type-I (right). d IF for CK8 (left), CK8, YFP, and Hoechst 33258 (center-left), vimentin (center-right), or vimentin, YFP, and Hoechst 33258 (right). Scale bars (a) 250 μm and (b–d) 100 μm