Table 4.
The associations between the IL-10 -1082 A/G polymorphism and clinical characteristics of AKI
| Characteristics | |||
|---|---|---|---|
| AG vs. AA | GG vs. AA | AG + GG vs. AA | |
| OR (95 %CI); P-value | OR (95 %CI); P-value | OR (95 %CI); P-value | |
| APACHE II score | |||
| ≥22/<22 | 1.32(0.83–2.12); 0.241 | 2.20(1.04–4.67); 0.037 | 1.47(0.94–2.29); 0.090 |
| RRT | |||
| Yes/No | 1.00(0.61–1.62); 0.986 | 1.23(0.58–2.62); 0.590 | 1.04(0.66–1.65); 0.865 |
| AKI Stage | |||
| Stage 2/Stage 1 | 1.05(0.62–1.77); 0.867 | 1.35(0.56–3.26); 0.500 | 1.10(0.67–1.81); 0.716 |
| AKI Stage | |||
| Stage 3/Stage 1 | 1.00(0.53–1.88); 0.992 | 1.72(0.65–4.57); 0.275 | 1.12(0.62–2.02); 0.714 |
| Baseline eGFR < 60 ml/min/1.73m2 | |||
| Yes/No | 1.97(1.19–3.25); 0.008 | 1.19(0.56–2.54); 0.659 | 1.76(1.11–2.80); 0.017 |
| Cause of AKI | |||
| Ischemic/Non-Ischemic | 2.36(1.40–3.97); 0.001 | 2.42(1.11–5.28); 0.024 | 2.37(1.44–3.89); 0.001 |
| Cause of AKI | |||
| Sepsis/Non-sepsis | 2.48(1.33–4.63); 0.004 | 3.77(1.60–8.86); 0.001 | 2.72(1.50–4.93); 0.001 |
OR, Odds Ratios; 95 %CI, 95 % Confidence Intervals; APACHE, Acute Physiology and Chronic Health Evaluation; RRT, renal replacement therapy; eGFR, estimated glomerular filtration rate; AKI, acute kidney injury. Bold values are statistically significant (P < 0.05)