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. 2021 Jun 5;23(9):1078–1084. doi: 10.1016/j.jmoldx.2021.05.012

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© 2021 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc.

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The symptomatic spreaders exhibit the lowest cycle threshold (Ct) values as a population. A: Separation of positive cases into spreaders and nonspreaders, with or without symptoms. The n of the cases in each population is indicated. B and C: Scatter plots of Ct values expressed as means ± SEM (B) or median ± interquartile intervals (C). Ct values of the indicated populations are compared. D: The histogram of the distribution of Ct values. E: The cumulative frequency of Ct values. Dashed lines indicate the cumulated percentage of each population at the Ct value of 24. At this Ct value and below, there is a higher percentage of symptomatic spreader cases (66.2%) than asymptomatic nonspreader cases (48.7%). The percentage of cases of the other groups falls between the two. Ct values of the indicated populations are compared. P > 0.05 (one-way analysis of variance; B and C).