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. 2021 Jun 5;19:3864–3875. doi: 10.1016/j.csbj.2021.05.054

Fig. 1.

Fig. 1

Month wise occurrence of key recurrent SARS-CoV-2 mutations. (A) Month wise occurrence of top 10 recurrent SARS-CoV-2 mutations. (A: Last column) Emergence of new highly recurrent (HR) mutations that occur after August 2020. Note that the emergence of N protein:A220V, ORF10 protein:V30L, Spike:A222V and Spike:L18F is seen only after July 2020. (B) Decrease in the percentage frequency of some of the mutations which were highly recurring before March 2020. Note that the occurrence of ORF8 protein:L84S and ORF3a protein:G251V is completely reduced after May 2020 and the occurrence of NSP6:L37F is reduced from HR to moderately recurrent (MR) after March 2020. (C) Diagram illustrating the rise (before Spike:D614G becomes dominant) and fall (after Spike:D614G takes over the wild type) of ORF8 protein:L84S and ORF3a protein:G251V. (D) Emergence of new mutations in non-coding region that occur at significantly high recurrence (HR). Note that 5′UTR:C241T mutation started occurring after Feb 2020 and 5′UTR:G204T and ORF10 stemloop:G29645T mutations started occurring after August 2020.