Comparison between the two-step approaches via electrophilic or nucleophilic pathway and the arylboronic acid method for the ¹²⁵I-iodination and ²¹¹At-astatination of the 9E7.4 mAb.

Method	RCYs (%)		Activity yieldc (MBq)		Specific activityc (MBq mg−1)		Duration time (min)
	125I	211At	125I	211At	125I	211At
Two-step electrophilica	—	20–30	—	5.5	—	24.4	200 ± 10
Two-step nucleophilicb	43	53–57	12.9	13.2	57.3	58.7	140 ± 10
This work	80	56–68	24	16.1	66.7	119	90 ± 10

^a[²¹¹At]SAB prepared from the tin precursor with N-chlorosuccinimide as oxidizing agent before the conjugation to the mAb (n = 2).

^b[¹²⁵I]SIB or [²¹¹At]SAB prepared from the aryliodonium salt with sodium sulfite as reducing agent before conjugation to the mAb (n = 5).

^cStarting with 30 MBq.