Scheme 5. MnI catalyzed β-methylation of secondary alcohols 7 with CO and H2. Reaction conditions: same as Scheme 4. aModified conditions: 7 (0.5 mmol), Mn-complex 1 (2 mol%), CO (5 bar), H2 (15 bar), NaOtBu (1 mmol), and toluene (0.8 mL) were heated in a high pressure reactor for 36 h. b7 (0.5 mmol), Mn-complex 1 (2 mol%), CO (8 bar), H2 (24 bar), NaOtBu (2 mmol), and toluene (0.8 mL) were heated in a high-pressure reactor for 36 h.
