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Interaction of SARS-CoV-2 with ACE-2 receptors in lungs: the lysosomal proteases, such as elastase, and cell surface proteases TMPRSS2 could induce activation of SARS-CoV-2 S-protein for membrane fusion through ACE-2 receptors, which consequently causes lung tropism through endosome formation, multiple virion replication, and exocytosis
