Parkinson’s disease (PD) |
Tremors, dyskinesia |
Chronic defects in the mesolimbic system of basal ganglia mainly in the dopaminergic neurons; enhanced neurodegeneration |
[148, 149] |
Alzheimer’s disease (AD) |
Cognitive decline and memory loss |
Enhanced accumulation of amyloid-beta plaques in the brain; enhanced neurodegeneration |
[130] |
Multiple sclerosis |
Severe lymphopenia, optic neuritis |
Extensive demyelination |
[155] |
Guillain–Barré syndrome (GBS) |
Progressive flaccid paralysis, dyssynergia, areflexia |
Severe autonomic dysfunction, respiratory failure, demyelination through immune response in the peripheral nervous system (PNS) |
[163, 165, 166] |
Miller Fisher syndrome |
Diplopia, balance disturbances, and areflexia |
Chronic demyelination of cranial and facial nerves |
[169] |
Acute disseminated encephalomyelitis (ADEM) |
Encephalopathy, transverse myelitis, weakness, numbness of the limbs, and urinary disorders |
Immune-mediated inflammatory demyelination affecting the white matter of brain and spinal cord |
[172] |