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. 2021 Jun 5;58(9):4535–4563. doi: 10.1007/s12035-021-02399-6

Table 2.

List of neurological disorders due to SARS-CoV-2 infection

Neurological diseases Disease—clinical manifestations SARS-CoV-2-induced clinical manifestations References
Parkinson’s disease (PD) Tremors, dyskinesia Chronic defects in the mesolimbic system of basal ganglia mainly in the dopaminergic neurons; enhanced neurodegeneration [148, 149]
Alzheimer’s disease (AD) Cognitive decline and memory loss Enhanced accumulation of amyloid-beta plaques in the brain; enhanced neurodegeneration [130]
Multiple sclerosis Severe lymphopenia, optic neuritis Extensive demyelination [155]
Guillain–Barré syndrome (GBS) Progressive flaccid paralysis, dyssynergia, areflexia Severe autonomic dysfunction, respiratory failure, demyelination through immune response in the peripheral nervous system (PNS) [163, 165, 166]
Miller Fisher syndrome Diplopia, balance disturbances, and areflexia Chronic demyelination of cranial and facial nerves [169]
Acute disseminated encephalomyelitis (ADEM) Encephalopathy, transverse myelitis, weakness, numbness of the limbs, and urinary disorders Immune-mediated inflammatory demyelination affecting the white matter of brain and spinal cord [172]