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. 2021 Jun 5;184(15):3949–3961.e11. doi: 10.1016/j.cell.2021.06.002

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© 2021 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Neutralization of variants of concern and variants of interest by the REGEN-COV combination and individual antibodies

Neutralization curves and (A) Neutralization fold-decrease (B) relative to parental D614G variant. Full UK B.1.1.7 (H69del, V70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), South African B.1.351 (D80Y, D215Y, L241del, L242del, A243del, L242del, K417N, E484K, N501Y, D614G, A701V) and P.1 (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F) variants were assessed. Key RBD residues from B.1.429 California (L452R) and B.1.617.1 India (L452R/E484Q) and B.1.617.2 India (L452R/T478K) variants were assessed. The E484K variant has been identified in many global lineages, including the B.1.526 New York, P.2 Brazil and B.1.618 India lineages. Data represent three technical replicates.