Figure 2.
In vitro escape with individual antibodies and antibody combinations
VSV-spike recombinant virus was passaged under pressure of individual antibodies or antibody combinations.
(A) Passage number during which the virus completely escaped neutralizing activity of the antibodies as evidenced by the cytopathic effect (CPE) is shown as “complete escape” for wells where antibody concentration was 10 μg/mL or above or “partial escape” for wells where antibody concentration was 1–10 μg/mL.
(B) Neutralization potency of the two mAb REGN10987+REGN10933 combination and the three mAb REGN10987+REGN10933+REGN10987+REGN10985 combination along with individual mAbs. Data represent three technical replicates.
(C) Two views of the RBD-REGN10933-REGN10987-REGN10985 model. RBD is colored white; REGN10933 is shown blue, REGN10987 is shown in red and REGN10985 is shown in green. Surface representation of the RBD in white with contact patches for each antibody, colors as in (A).