Figure 3.

Frequency of SARS-CoV-2 spike variants identified in viruses from lungs of hamsters treated with either REGN10987 or REGN10933 as monotherapy or with the REGEN-COV combination in both prophylactic and treatment settings

(A) Study design (n = 5 for placebo group, n = 10 for treatment groups).

(B and C) Graphs show the distribution and frequencies of amino acid variants across the spike protein sequence identified in samples from the (B) prophylactic or (C) treated groups. Mutated sites are indicated with gray lines and dots show the frequency of variants in each animal. The color of each dot indicated the dose used. Spike protein domain is color coded as indicated, and all amino acid changes in RBD are labeled. Study represents one biological replicate.

See also Table S3.