Fig. 2.

Mutations and deletions of the hcHLA-I genes in MHC-I^NEG and MHC-I^POS DLBCL. Genetic lesions affecting B2M and other genes implicated in antigen presentation in 42 MHC-I^NEG (A) and 32 MHC-I^POS (B) DLBCL primary cases, color-coded according to mutation type. Cross marks indicate germline homozygous HLA-I alleles, where allele-specific LOH cannot be predicted; on the right side, “A” and “B” denote separate alleles (see Materials and Methods and SI Appendix, Tables S2–S4 for details on mutation type).