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. 2021 May 28;118(22):e2104504118. doi: 10.1073/pnas.2104504118

Fig. 5.

Fig. 5.

Increased risk of DLBCL in individuals with homozygous germline HLA-I genes. (A and B) Percentage of patients harboring homozygous germline HLA-I genes in the indicated cancers (A, TCGA dataset; B, UK BioBank dataset). Dotted line indicates the percentage in a matched normal population (23% for UK BioBank samples and 21% for TCGA samples, based on GTEx; *P < 0.05, binomial test, 95% CI). NSCLC and lung cancer are shown as a reference category for lack of enrichment. See also SI Appendix, Fig. S5. (C) ORs of DLBCL in patients with homozygous germline HLA-I genes as compared to normal individuals or to patients with other cancer diagnoses. BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; CHL, classical Hodgkin lymphoma; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; NSCLC, nonsmall cells lung cancer; UCEC, uterine corpus endometrial carcinoma.