Fig. 4. Representative in vivo axial MR images of the tumor region in a Balb/c mouse bearing subcutaneous TS/A tumor. (A) T2w MR image, (B) uncontrasted (pre) T1w MR image, (C) T1w MR image 2 min after the injection of Gd-HPDO3A (0.15 mmol kg−1) and (D) T1w MR image 2 min after the co-injection of Gd-HPDO3A (0.15 mmol kg−1) and HPTS (0.45 mmol kg−1). B0 = 7.1 T, room temperature. (E) Tumor enhancement curves after injection of Gd-HPDO3A (0.15 mmol kg−1) or Gd-HPDO3A/HPTS adduct (0.15 mmol kg−1/0.45 mmol kg−1, 1 : 3 mol/mol) (mean of 3 animals).
