K a and Rb of interaction between GBCAs and pyrene derivatives in buffer, pH = 7.0 ± 0.1 (T = 25 °C, B0 = 0.5 T).
| r 1p a (mM−1 s−1) | K a (M−1) | r b (mM−1 s−1) | R 1 (s−1) GBCA : pyrene (1 : 3) | |
|---|---|---|---|---|
| Gd-HPDO3A/HPTS | 4.6 | 628 | 6.9 | 6.7 |
| Gd-DO3A-Butrol/HPTS | 5.0 | 1157 | 7.9 | 7.6 |
| Gd-DOTA/HPTS | 4.2 | 174 | 7.4 | 5.7 |
| Gd-DTPA/HPTS | No interaction | |||
| Gd-DTPABMA/HPTS | No interaction | |||
| Gd-BOPTA/HPTS | No interaction | |||
| Gd-HPDO3A/HPDS | 4.6 | 124 | 10.9 | 6.9 |
| Gd-HPDO3A/PTS | 4.6 | 177 | 7.3 | 6.1 |
a
r 1p = relaxivity for 1 mM Gd-complex in the absence of pyrenes.