Fig. 6.

IFN-γ deficiency negates the effects of DLL1 overexpression on tumor growth, CD8⁺ T cell tumor infiltration, and vessel perfusion in EO771 breast tumor model. EO771-R1 and EO771-L1 breast tumor cells were inoculated orthotopically in WT and IFN-γ knockout mice (IFN-γ^−/−). Tumor size and tumor blood vessel perfusion were recorded and analyzed as described in Fig. 1. (A) The tumor growth curves. (B) The proportions of tumor-infiltrating CD8⁺ and CD4⁺ T cells. (C) Tumor blood vessel perfusion and vessel density in EO771-R1 and EO771-L1 breast tumors in WT or IFN-γ^−/− mice. The significance was determined by one-way ANOVA. Data are from one experiment representative of three independent experiments with similar results (n = 7 to 8 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001, ns, no significant difference.