Fig. 3. Tolerability of SQ3370 as compared to Dox and clinically tested Dox-based treatments in rodents. (A) The cumulative MTD of SQ3370 in mice was determined to be 383 mg kg−1 (76.6 mg per kg per day × 5 days), representing a 19.1-fold enhancement over the experimentally determined single-dose MTD of conventional Dox. (B) In rats, a cumulative dose of 107.5 mg kg−1 (21.5 mg per kg per day × 5 days) was tolerated without overt toxicities, a 10.8-fold margin over the conventional Dox MTD administered as 4 weekly doses.40 Previous Dox-based treatments have only been able to advance the MTD up to 60 mg kg−1 in mice40 and up to 45 mg kg−1, administered in two doses 22 days apart, in rats.41 All doses here are represented in Dox eq.
