Fig. 1.

Introgressed segments in EPAS1 and the genome-wide match rate with archaic individuals. This figure shows the density distribution of match rate to archaic individuals (Altai Denisovan or Neanderthal) in putatively archaic introgressed segments in 38 Tibetans, inferred by the SPrime program using Africans (YRI) as the outgroup. The match rate is defined as the proportion of alleles at the SPrime diagnostic polymorphic sites in a putatively introgressed segment that are present in the genome of archaic individuals at those positions (7). For a given segment, a match rate of 0 denotes that at a given set of diagnostic sites inferred by SPrime, none of the alleles at those sites match the corresponding alleles in the sequenced archaic human. The color range denotes the density of the contours, with red indicating high density and yellow indicating low density. The red star represents the matching coordinates for the introgressed segment within the EPAS1 gene.