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. 2021 May 28;118(22):e2020803118. doi: 10.1073/pnas.2020803118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Timeline of three Denisovan introgression events in Asia, and the selection of the adaptive EPAS1 allele. This figure is inspired by figure 4 in Jacobs et al. (29) that portrays three distinct Denisovan lineages (D0, D1, and D2), their inferred introgression times, and the split times (measured from the present) between them. Time estimates for D1 and D2 are from Jacobs et al. (29) using Papuan data, and the estimate for the East Asian-specific (D0) introgression time and the selection time in Tibetans come from this study.