Table 1.

Case Definitions for MIS-C (Obtained From WHO)

Children and adolescents aged 0–19 years with fever ≥3 days

AND two of the following:

1. Rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet)

2. Hypotension or shock

3. Features of myocardial dysfunction pericarditis, valvulitis or coronary abnormalities (including echocardiographic findings or elevated troponin/NT-proBNP)

4. Evidence of coagulopathy (based on PT, PTT, and elevated D-dimer levels)

5. Acute gastrointestinal problems (diarrhea, vomiting or abdominal pain)

AND

Elevated markers of inflammation, such as ESR, CRP and procalcitonin

AND

No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal or streptococcal shock syndromes

AND

Evidence of COVID-19 (RT-PCR assay, antigen test or serology positivity) or possible contact with a patient with COVID-19

Consider this syndrome in children with features of typical or atypical Kawasaki disease or toxic shock syndrome.