Fig. 3. BL ABS probe for FAAH activity. (a) Scheme of CycLuc1 amide hydrolysis by FAAH to CycLuc1 and interaction with luciferase to produce BL signal. (b) BL imaging with CycLuc1 and CycLuc1 amide in mice treated with vehicle or a FAAH inhibitor. (c) Total photon flux from the brain quantified as a function of inhibitor concentration and BL signal normalized to vehicle signal. Error bars = SEM (n = 3). Adapted with permission from ref. 19, Copyright 2015 American Chemical Society. Future permissions related to the adapted figure should be directed to the American Chemical Society.
