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. 2021 Jan 21;12(9):3295–3307. doi: 10.1039/d0sc06623k

Probe-modified kinases and binding sites from respective domains detected in TH211-treated Jurkat cells.

Uniprot Gene name Modified sites Domain name
O95747 OXSR1 229|227| Protein kinase domain
P05771 PRKCB 518|515| Protein kinase domain
P05771 PRKCB 209| C2 domain
P06239 LCK 192|209| SH2 domain
P06239 LCK 470|394|441| Protein kinase domain
P06493 CDK1 286|181|270| Protein kinase domain
P16591 FER 714| Protein kinase domain
P17252 PRKCA 515|512|504| Protein kinase domain
P17252 PRKCA 195|232|209| C2 domain
P19367 HK1 346| Hexokinase domain
P19784 CSNK2A2 308| Protein kinase domain
P23743 DGKA 240| Zinc finger phorbol-ester/DAG-type
P24941 CDK2 236|237| Protein kinase domain
P27361 MAPK3 280| Protein kinase domain
P28482 MAPK1 263| Protein kinase domain
P36507 MAP2K2 233|187|101| Protein kinase domain
P41240 CSK 97| SH2 domain
P41240 CSK 67|64| Src homology 3 (SH3) domain
P43403 ZAP70 506|372| Protein kinase domain
P43403 ZAP70 164| SH2 domain
P49840 GSK3A 355| Protein kinase domain
P52789 HK2 398|401| Hexokinase domain
P68400 CSNK2A1 307|182| Protein kinase domain
P78527 PRKDC 2965|3168|2936|3475| FAT domain
Q00534 CDK6 257|43| Protein kinase domain
Q02750 MAP2K1 97| Protein kinase domain
Q13131 PRKAA1 190|247| Protein kinase domain
Q13153 PAK1 429| Protein kinase domain
Q13177 PAK2 408| Protein kinase domain
Q13555 CAMK2G 231| Protein kinase domain
Q15118 PDK1 365| Histidine kinase core domain
Q16539 MAPK14 249|182|103| Protein kinase domain
Q16644 MAPKAPK3 263|76| Protein kinase domain
Q16774 GUK1 53| Guanylate kinase-like domain
Q8NEV1 CSNK2A3 307|182| Protein kinase domain
Q8TBX8 PIP4K2C 384| Phosphatidylinositol phosphate kinase (PIPK) domain
Q96KB5 PBK 100|74| Protein kinase domain
Q96S44 TP53RK 60|67| Protein kinase domain
Q99986 VRK1 194|213|98|113|107|311|188|317|187|147|214|302|314| Protein kinase domain