Fig. 5. Organic–inorganic nanocomposites for bio-sensing through energy transfer, secondary absorption and ACIE-based signal intensity response in the NIR-II window. (a) Schematic of the energy transfer based organic–inorganic nanocomposite for bio-sensing. (b) ONOO− response spectra of A1094 dye. (c) NIR-II bioimaging of the TBI model after V&A@Ag2S sensor administration. Reproduced from ref. 38 with permission from Wiley-VCH, Copyright 2019. (d) Schematic of the secondary absorption based organic–inorganic nanocomposite for bio-sensing. (e) NIR-II luminescence emission response of the sensor in the presence of H2O2. (f) Ratiometric (blue I980/I1180) images of microneedle patches before and after acute inflammation. Reproduced from ref. 61 with permission from Wiley-VCH, Copyright 2018. (g) Schematic of the ACIE based organic–inorganic nanocomposite for bio-sensing. (h) Anatomical structure of the mouse lymphatic system and the ratiometric luminescent imaging of healthy and inflamed mouse lymphatic systems. Reproduced from ref. 62 with permission from American Chemical Society, Copyright 2019.
