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. 2021 Jan 28;12(11):3876–3884. doi: 10.1039/d0sc05411a
graphic file with name d0sc05411a-u1.jpg
Compound 8a 6t 8b 8c 8d 8e 8f 8g 8h 8i 8j
R1 CO2H H CO2H CO2H CO2H CO2H CO2H CO2H CO2H H CO2H
R2 H H H H H H H H H H H
R3 H H CH3 OBn CF3 NO2 OH SO3H CO2H CO2H H
R4 H H H H H H H H H H CO2H
R5 H H H H H H H H H H CO2H
X CH CH CH CH CH CH CH CH CH CH CH
IC50a (μM) 9.3 >100 14.8 12.7 4.2 3.2 >100 >100 >100 40.1 >100
a

Half maximal inhibitory concentrations (IC50 values) obtained from in vitro TDP1 gel-based assays.