Fig. 5. Polymeric condensates preferentially exclude Aβ-42 and do not affect fibril formation. (A) and (B) Brightfield (left) and fluorescence (right) confocal images of 1 μM Aβ-42 labelled with Atto-488 incubated with coacervates formed by the zwitterionic polymer (A) and by the LCST polymer (B). (C) Aggregation profiles of 5 μM Aβ-42 in the absence (black) and presence of 20 μM zwitterionic polymer (orange) and 20 μM LCST polymer (green) at 27.5 °C.
