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Scheme 1. Generic fuel-driven CRN, where both formation and degradation pathways are catalysed. Reactant (R) is converted into product (P) by supplying fuel (F1) and concomitantly generating waste (W1), catalysed by C1. P is unstable and only transiently formed and degrades again with reagent (F2), generating R and waste (W2), catalysed by C2.