Scheme 2. S_NAr reaction of 1 in DMF with and without propargylamine. Reactions performed on 0.2 mmol scale of 1, 1.1 eq. of amine, 3.0 eq. of DIPEA and in 0.2 M concentration of DMSO for 16 hours. *Recovery and yield determined in duplicate by ¹H NMR using 1,3,5-trimethoxybenzene as an internal standard.