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. 2021 Feb 3;12(12):4519–4525. doi: 10.1039/d0sc05442a

Scheme 3. Phthalimide stability in the presence of excess amine nucleophile. Reactions performed on 0.2 mmol scale of 1, 3.0 eq. of amine, 3.0 eq. of DIPEA and 0.2 M concentration in DMSO for 16 hours. Yield determined by 1H NMR using 1,3,5-trimethoxybenzene as an internal standard. Isolated yields are shown in parentheses.

Scheme 3