Skip to main content
. 2021 Feb 8;12(13):4810–4818. doi: 10.1039/d0sc06744j

Fig. 9. Multiplexed analysis of the p53 and BRCA1 genes by a mixture consisting of Fl-loaded hp9-modified NMOFs and Rh 6G-loaded hp10-modified NMOFs using the HCR-amplified CRET-induced analysis of the two genes upon (panel A) subjecting the mixture to variable concentrations of p53: (a) 0 nM; (b) 1 nM; (c) 20 nM; (d) 50 nM; (e) 200 nM; (panel B) subjecting the mixture to variable concentrations of BRCA1: (a) 0 nM; (b) 5 nM; (c) 50 nM; (d) 100 nM; (e) 333 nM; and (panel C) subjecting the mixture to variable concentrations of p53: (a) 0 nM; (b) 1 nM; (c) 10 nM; (d) 50 nM; (e) 200 nM (curve (b) in panel II), and to variable concentrations of BRCA1: (a) 0 nM; (b) 5 nM; (c) 50 nM; (d) 100 nM; (e) 500 nM (curve (a) in panel II). Error bars derived from N = 3 experiments.

Fig. 9