Skip to main content
. 2021 Feb 22;12(15):5616–5620. doi: 10.1039/d0sc07047e

Optimization of reaction conditionsa.

graphic file with name d0sc07047e-u1.jpg
Entry Base Yieldb (3a, %)
1 LiHMDS 84 (75)c
2 nBuLi 48
3 tBuOLi 33
4 iPrMgCl 35
5 CH3MgBr 21
a

Reactions conditions: 1 (0.1 mmol), 2a (0.12 mmol), base (0.105 mmol) in cyclohexane (2 mL), rt, 0.5 h.

b

Determined by GC.

c

Isolated yield.