Fig. 5. (a) Programmed triggered unlocking of nanocavities in an origami dimer-tile structure using ATP and K+ ions as unlocking triggers: treatment of dimer I with ATP and H1/H2 unlocks the ATP-responsive origami tile leading to the nanocavity-containing dimer in structure II. Subjecting dimer I to K+ ions and H1/H2 leads to the unlocking of the G-quadruplex-responsive tile and to the formation of the nanocavity-containing dimer in structure III. Treatment of origami dimer I with the two triggers ATP and K+ ions and H1/H2 yields the double nanocavity-containing origami dimer, structure IV. (b) AFM image corresponding to dimer I and the respective cross-sectional analysis. (c), (d) and (e) AFM images corresponding to the origami dimer structures and the respective cross-section analysis of the origami dimer structures, II, III and IV. (b–e), Scale bars: 200 nm. (f) Yields of origami structures corresponding to closed origami dimer I and to the nanocavity-containing origami structures II, III and IV generated by the respective triggers.
