Fig. 4. Cell viability assay using cultured β-cells exposed to CGRP, amylin, and amylin : CGRP. 832/13 rat β-cells were either left untreated (NT) or exposed to 1 ng mL−1 IL-1β and 2 mM camptothecin (CT) compared with 5 μM of amylin, CGRP, and amylin plus CGRP for 18 h. ****, p < 0.0001 versus NT using one-way ANOVA. n = 4–6 per group. When compared to CT, the effects of amylin, CGRP, or amylin : CGRP on cellular viability are minor, although amylin has a stronger effect than the other two conditions.
