Table 2.
Pharmacokinetic parameters of 7-hydroxymitragynine after oral (1 mg/kg) dose in female beagle dogsa
Parameter | Oral |
---|---|
Cmax (ng/mL) | 56.4 ± 1.6 |
Tmax (h) | 0.14 ± 0.1 |
AUC0-inf (h·ng/mL) | 178.6 ± 25.9 |
Cl/F (L/h/Kg) | 4.4 ± 0.6 |
Vd/F (L/Kg) | 23.8 ± 6.7 |
T1/2 (h) | 3.6 ± 0.5 |
N = 3, values are mean ± SEM
Abbreviations: AUC0-inf = area under the plasma concentration-time curve from 0 to infinity, Cl= clearance, Cmax = plasma peak concentration, T1/2 = elimination half-life, Vd = volume of distribution, Tmax = time to reach Cmax, F = bioavailability fraction