Table 1.
Approved Drugs for RA Treatment
| Drug | Structure | Mode of Action | Pivotal Studies |
|---|---|---|---|
| Infliximab | Chimeric monoclonal antibody | Anti TNF inhibitor | ATTRACT Maini 1999 |
| ASPIRE St Clair 2004 | |||
| BEST Yvonne 2007 | |||
| Etanercept | Fusion protein | Anti TNF inhibitor | ERA Barthon 2000 |
| COMET Emery 2008 | |||
| TEMPO Klareskog 2004 | |||
| Adalimumab | Human monoclonal antibody | Anti TNF inhibitor | ARMADA Weinblatt 2003 |
| PREMIER Breedvelt 2006 | |||
| OPTIMA Kavanaugh 2013 | |||
| Certolizumab | Pegylated human monoclonal antibody | Anti TNF inhibitor | RAPID 1 Keystone 2008 |
| RAPID 2 Smolen 2009 | |||
| FAST4WARD Fleischmann 2009 | |||
| Golimumab | Human monoclonal antibody | Anti TNF inhibitor | GO BEFORE Emery 2009 |
| GO FORWARD Keystone 2009 | |||
| GO AFTER Smolen 2009 | |||
| Abatacep | Human fusion protein | T Cell co stimulatory inhibition (CD80/CD86) | ABA in MTX RESISTENT PATIENTS Kremer 2006 |
| ABA in TNF REFRACTORY PATIENTS Genovese 2005 | |||
| ACQUIRE Genovese 2011 | |||
| Tocilizumab | Human monoclonal antibody | AntiIL 6 inhibitor receptor | TOWARD Genovese 2008 |
| RADIATE Emery 2008 | |||
| AMBITION Jones 2010 | |||
| ACT-RAY Dougados 2013 | |||
| Sarillumab | Human monoclonal antibody | AntiIL 6 inhibitor receptor | SARIL-RA-MOBILITY Huizinga 2014 |
| TARGET Fleischmann 2017 | |||
| Rituximab | Chimeric monoclonal antibody | B cell depletion (anti CD20) | DANCER Emery 2006 |
| REFLEX Cohen 2006 | |||
| Tofacitinib | Small molecule | JAK1 and JAK3 inhibitor | ORAL Start |
| ORAL Sync | |||
| ORAL Scan | |||
| ORAL Solo | |||
| ORAL Standard | |||
| ORAL Step | |||
| Oral Strategy | |||
| Baricitinib | Small molecule | JAK 1 and JAK 2 inhibitor | RA Begin |
| RA Beacon | |||
| RA Bean | |||
| RA Build | |||
| RA Beyond | |||
| Upadacitinib | Small molecule | JAK1 inhibitor | SELECT Netx |
| SELECT Beyond | |||
| SELECT Monotherapy | |||
| SELECT Early | |||
| SELECT Compare | |||
| SELECT Choice | |||
| Filgotinib | Small molecule | JAK1 inhibitor | FINCH 1 |
| FINCH 2 | |||
| FINCH 3 | |||
| FINCH 4 |