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. 2021 Jun 1;14:2003–2014. doi: 10.2147/IDR.S309051

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© 2021 Elagan et al.

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The six mechanisms involved in colon carcinogenesis by Bacteroides fragilis toxin (BFT). Colon carcinogenesis due to BFT is mediated by the induction of T-cell factor- dependent β-catenin pathway (TSF- β-catenin), cleavage of E-Cadherin, stimulation of IL-8 productionleading to the persistent proliferation of gut epithelial cells. BFT induces the production of reactive oxygen species (ROS), DNA damage, and gut epithelial cell proliferation via the induction of spermine oxidase (SMO) and cellular inhibitor of apoptosis protein-2 (c-IAP2). Created in ©BioRender.com.