Fig. 1.

Receiver operating characteristic curve for investigated markers. Arrows donate to the cut value for investigated markers: for VEGF, the cutoff was 38 ng/ml with sensitivity at 92.35% and specificity at 96.8% at standard error 0.0077 and CI% 0.955–0.991, area under the curve 0.978; for cyclin D1, the cutoff was 38 ng/ml with sensitivity at 91.8% and specificity at 96% at standard error 0.008 and CI% 0.952–0.989, area under the curve 0.975; and for miR-373, the cutoff was 360 ng/ml with sensitivity at 90.8% and specificity at 98.4% at standard error 0.007 and CI% 0.958–0.992, area under the curve 0.98