Table 2.

Cox regression models (stratified by MS center) to develop lymphopenia during DMF treatment

Patients	n = 1134
	HR	95% CIs	p value
Age (each year)	1.03	1.02–1.05	< 0.001
Disease duration (each year)	0.99	0.97–1.01	0.484
Female sex	1.55	1.10–2.18	0.012
EDSS	1.02	0.92–1.14	0.655
Naïves	1.34	0.94–1.91	0.103

MS multiple sclerosis, DMF dimethyl fumarate, HR hazard ratio, 95% CIs 95% confidence intervals, EDSS Expanded Disability Status Score

In bold are reported significant difference at a two-sided α level < 0.05