Fig. 4.

Levels of CSF KIF5A positively correlate with measures of disease severity in 2-year follow-up of relapsing–remitting patients within Cardiff cohort (n = 35). Levels of CSF KIF5A measured by ELISA significantly correlate with change in EDSS (a), MSSS (b) and ARMSSS (c) score as recorded from LP and average 24-month follow-up (range 13–40 months). KIF5A values expressed as mean. Statistical test used: non-parametric Spearman’s rank correlation coefficient, *p < 0.05. ARMSSS age-related multiple sclerosis severity score, EDSS expanded disability status score, KIF5A kinesin superfamily motor protein 5A, MSSS multiple sclerosis severity score