Table 4.

Multiple regression analysis of KIF5A within the Cardiff cohort

Protein	n	Variables	Coefficient	Standard error	t	p value	95% Confidence intervals
KIF5A (ng/mL)	101	CIS vs RRMS	0.081	0.058	1.39	0.176	− 0.039	0.200
		CIS vs progressive MS	0.333	0.088	3.82	0.001	0.154	0.515
		RRMS vs progressive MS	0.254	0.077	3.29	0.003	0.095	0.413
	102	Age at LP	− 0.005	0.004	− 1.18	0.250	− 0.013	0.004
	102	Storage time	− 0.012	0.008	− 1.59	0.125	− 0.028	0.004
	102	Sex	0.026	0.058	0.45	0.654	− 0.094	0.147
	102	rs703842 GG vs AA	0.173	0.157	1.10	0.281	− 0.151	0.497
		rs703842 AG vs AA	0.151	0.060	2.53	0.019	0.028	0.275
	102	rs12368653 GG vs AA	0.023	0.090	0.26	0.799	− 0.163	0.210
		rs12368653 AG vs AA	0.063	0.072	0.87	0.391	− 0.085	0.211
	70	MSSS	0.015	0.017	0.91	0.371	− 0.020	0.051
	83	ARMSSS	− 0.030	0.022	− 1.35	0.191	− 0.765	0.016
	60	Relapsing at LP	− 0.139	0.124	− 1.12	0.273	− 0.394	0.116
	67	First inter-attack interval	0.000	0.004	0.12	0.904	− 0.007	0.008

Bonferroni correction to the required αλπηα 0.05 cut-off for significance has been applied. Significant associations highlighted in bold

AA homozygous adenine, AG heterozygous adenine/guanine, CIS clinically isolated syndrome, ARMSSS age-related multiple sclerosis severity score, GG homozygous guanine, EDSS expanded disability status score, KIF kinesin superfamily motor protein, LP lumbar puncture, MSSS multiple sclerosis severity score, RRMS relapsing–remitting multiple sclerosis