Table 2.

Top 10 differentially methylated CpG sites associated with binary response and ΔHDRS.

CpG	CHR	Base pair position	p-Value	FDR	Annotated genes
Binary response
cg10005358	8	9505300	7.2 × 10−8	0.0498	TNKS
cg22813821	12	72148853	2.2 × 10−6	0.5940	RAB21
cg11062168	15	35262789	2.6 × 10−6	0.5940	AQR
cg12305855	4	160216262	5.1 × 10−6	0.6072	RAPGEF2
cg19869734	2	107154571	9.8 × 10−6	0.6072
cg08133350	19	50321326	9.9 × 10−6	0.6072	MED25
cg23870282	3	72897792	1.0 × 10−5	0.6072	SHQ1
cg00101693	10	70715578	1.0 × 10−5	0.6072	DDX21
cg23367665	1	231414306	1.1 × 10−5	0.6072
cg00511318	17	56406260	1.1 × 10−5	0.6072	TSPOAP1;TSPOAP1-AS1
ΔHDRS
cg01294490	6	35656906	4.5 × 10−7	0.3106	FKBP5
cg10515948	2	242674491	1.3 × 10−6	0.4558	D2HGDH
cg02936535	17	7514491	3.8 × 10−6	0.7870	FXR2
cg11385008	2	11621166	6.1 × 10−6	0.7870
cg16377817	5	170845627	8.2 × 10−6	0.7870	FGF18
cg06668695	15	80213874	8.6 × 10−6	0.7870	ST20-MTHFS;ST20;ST20-AS1
cg08790000	11	67255752	9.0 × 10−6	0.7870	AIP
cg16306546	21	44183372	1.0 × 10−5	0.7870	PDE9A
cg19307750	1	241372556	1.1 × 10−5	0.7870	RGS7
cg03611990	6	96980568	1.2 × 10−5	0.7870	UFL1

CpG cytosine-phosphate-guanine, CHR chromosome, FDR false discovery rate.