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. 2021 Jun 5;12(6):579. doi: 10.1038/s41419-021-03872-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Live-imaging of AT explants of HFD-fed MacGreen mice (green: BODIPY-stained lipids, red: ATMs, movies provided as online supplement). A Degradation of adipocyte remnants in AT explants occurs in three distinct ways: efferocytosis (upper row), fragmentation (middle row), or CLS formation (lower row). B Representative overview images of living AT of chow-fed and HFD-fed mice. C Quantification of lipid diameter associated with either efferocytosis, fragmentation, or CLS formation (188 registered events in 40 movies from 6 independent experiments). D Quantification of lipid diameter in adipocytes of chow-fed or HFD-fed littermates (N = 3). Asterisks mark lipid remnants degraded by ATMs. Blue line indicates the threshold for efferocytosis. Scale bars = 25 µm.