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. 2021 May 6;2021(5):CD013623. doi: 10.1002/14651858.CD013623.pub2

Summary of findings 1. Reactive water surfaces compared with alternating pressure (active) air surfaces for preventing pressure ulcers.

Reactive water surfaces compared with alternating pressure (active) air surfaces for preventing pressure ulcers
Patient or population: preventing pressure ulcers
Setting: acute care setting and intensive care unit
Intervention: reactive water surfaces
Comparison: alternating pressure (active) air surfaces
Outcomes Anticipated absolute effects* (95% CI) Relative effect
(95% CI) № of participants
(studies) Certainty of the evidence
(GRADE) Comments
Risk with alternating pressure (active) air surfaces Risk with reactive water surfaces
Proportion of participants developing a new pressure ulcer
Follow‐up: median 10 days Study population RR 0.83
(0.35 to 1.93) 358
(2 RCTs) ⊕⊝⊝⊝
Very lowa,b It is uncertain if there is any difference between reactive water surfaces and alternating pressure (active) air surfaces in the proportion of participants developing a new pressure ulcer.
65 per 1,000 54 per 1,000
(23 to 125)
Time to pressure ulcer incidence Included studies did not report this outcome.
Support surface‐associated patient comfort Included studies did not report this outcome.
All reported adverse events Included studies did not report this outcome.
Health‐related quality of life Included studies did not report this outcome.
Cost effectiveness Included studies did not report this outcome.
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: Confidence interval; RR: Risk ratio
GRADE Working Group grades of evidenceHigh certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
Moderate certainty: we are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: our confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect.
Very low certainty: we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect.

aDowngraded twice for high risk of detection bias in 1 study contributing over 60% weight in the meta‐analysis and unclear overall risk of bias in another study.
bDowngraded twice for substantial imprecision as the optimal information size (OIS) was not met and the very wide confidence interval crossed RR = 0.75 and 1.25.