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. 2020 Nov 23;2(1):zqaa033. doi: 10.1093/function/zqaa033

Figure 1.

Figure 1.

Satellite cell depletion blunted higher muscle weights induced by PoWeR. (A) Study design for Sedentary (Sed) and PoWeR-trained satellite cell replete (SC+) and deplete (SC−) mice. The amount of weight in grams added to the wheel each week during PoWeR is indicated. (B) Endpoint body weights across all groups. (C) Average running volume after 4-weeks and 8-weeks of PoWeR. (D) Normalized muscle weight in the soleus. (E) Normalized muscle weight in the plantaris. Data are represented as mean ± SEM. Statistical analysis: two-way ANOVA with Tukey’s multiple comparisons test. PoWeR led to higher muscle weights at 4-weeks (P < 0.0001) and 8-weeks (P < 0.0001) in the soleus and at 4-weeks (P < 0.01) and 8-weeks (P < 0.0001) in the plantaris. There was a significant effect for satellite cell depletion blunting this adaptation. ††P < 0.01.