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. 2021 Jun 5;26:24. doi: 10.1186/s11658-021-00265-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — MiR-33a-5p exerted suppressive effects on PDAC cell proliferation, migration and invasion. A Expression level of miR-33a-5p was assessed by RT-qPCR in SW1990 and PANC-1 cells after transection with the miR-33a-5p mimics or miR-NC. B CCK-8 assay was used to evaluate changes in SW1990 and PANC-1 cell proliferation following transfection with miR-33a-5p mimics or miR-NC. C, D Cell migration and invasion were analyzed in SW1990 and PANC-1 cells following transfection with miR-33a-5p mimics or miR-NC. E BxPC-3 and ASPC-1 cells were transected with the miR-33a-5p inhibitor or miR-NC. After that, the expression level of miR-33a-5p was assessed by RT-qPCR. F Changes in proliferation of transfected BxPC-3 and ASPC-1 cells were evaluated by the CCK-8 assay. G, H Cell migration and invasion were analyzed in transfected BxPC-3 and ASPC-1. **p < 0.01, ***p < 0.001 vs. miR-NC or inhibitor NC group