Fig. 4.

RAP2A was inversely correlated with miR-33a-5p expression in PDAC. A Our meta-analysis included four microarray datasets regarding RAP2A mRNA expression in pancreatic cancer vs. normal tissues. Data are shown as the median rank of RAP2A through each dataset analysis. P-value for RAP2A was presented using the median ranked analysis for pancreatic cancer vs. normal tissues. B RAP2A mRNA levels analyzed using RT-qPCR in paired PDAC tissue samples and adjacent pancreatic tissues (n = 58). C An inverse association was identified between miR-33a-5p and RAP2A mRNA expression levels through Spearman correlation analysis (r = − 0.2959, p = 0.0241). (D) RAP2A mRNA levels were determined in BxPC-3, ASPC-1, SW1990, PANC-1 and HPNE cell lines. ***p < 0.001 vs. HPNE