Table 2.
Interactions of the methanol extract/compounds from R. abyssinicus and antibiotics against bacterial and yeast species
| Microorganisms | MeOH extract | Compound 2 | Compound 4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FICA | FICEx | FIC | Interpretation | FICA | FIC2 | FIC | Interpretation | FICA | FIC5 | FIC | Interpretation | |
| P. aeruginosa | 0.25 | 0.125 | 0.37 | Synergistic | 0.125 | 0.125 | 0.25 | Synergistic | 0.25 | 0.125 | 0.25 | Synergistic |
| S. flexneri | 0.125 | 0.125 | 0.25 | Synergistic | 0.031 | 0.25 | 0.281 | Synergistic | 0.0625 | 0.25 | 0.31 | Synergistic |
| S. aureus | 0.25 | 0.125 | 0.37 | Synergistic | 0.25 | 0.125 | 0.375 | Synergistic | 0.5 | 0.125 | 0.625 | Additive |
| MSSA01 | 0.125 | 0.0625 | 0.18 | Synergistic | 0.0625 | 0.5 | 0.5625 | Additive | 0.25 | 0.25 | 0.5 | Synergistic |
| MRSA03 | 0.125 | 0.125 | 025 | Synergistic | 0.0625 | 0.5 | 0.5625 | Additive | 0.25 | 0.125 | 0.375 | Synergistic |
| C. albicans | 0.125 | 0.0625 | 0.18 | Synergistic | 0.0625 | 0.0625 | 0.125 | Synergistic | 0.25 | 0.5 | 0.75 | Additive |
| C. neoformans | 0.0625 | 0.0625 | 0.125 | Synergistic | 0.0625 | 0.0625 | 0.125 | Synergistic | 0.25 | 0.5 | 0.75 | Additive |
FICA MIC of antibiotic tested in combination/MIC of antibiotic tested alone; FICEx MIC of extract tested in combination/MIC of extract tested alone; FIC2 MIC of compound 2 tested in combination with antibiotic/ MIC of compound 2 tested alone; FIC4 MIC of compound 4 tested in combination with antibiotic/ MIC of compound 4 tested alone; FIC: MIC of antibiotic tested in combination/MIC of antibiotic tested alone + MIC of extract/compound tested in combination/MIC of extract/compound tested alone; antibiotics: ciprofloxacin for bacteria and fluconazole for yeasts