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Platinum adducts acquisition in PEO1 and PEO4. a PEO1 incurs more adducts than PEO4 at the same dose of cisplatin, as measured by ICP-MS. b The difference in adduct formation is reflected in levels of enrichment for platinum target purine dinucleotides at the 5’ end of Pt-exo-seq reads. PEO1 and PEO4 were treated with concentrations of cisplatin that ICP-MS indicated would induce equal amounts of damage.
