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. 2021 Jun 5;21:189. doi: 10.1186/s12890-021-01558-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Constriction responses of the pulmonary arteries and veins to phenylephrine. Concentration-response curves to phenylephrine in segments of rats (N = 6–8) pulmonary arteries and pulmonary veins. The number of rats is the number of repetitions of each group. After pretreatment with propranolol or N[gamma]-nitro-L-arginine methyl ester (L-NAME) or both, arteries and veins were exposed to increasing concentrations of phenylephrine. Control group directly exposed to phenylephrine. Asterisk indicates artery segments pretreated with L-NAME were significance than segments pretreated with propranolol and combine propranolol and L-NAME. There were no significant difference in pulmonary arteries tension between pretreated with propranolol and combine propranolol and L-NAME. There were no significant difference in pulmonary veins tension among all groups. Where no error bar is visible the SEM is within the symbol. “*” means p < 0.05; “**” means p < 0.01. (one-way analysis of variance, Bonferroni post hoc comparison)