Table 5.

Structure and medical content of the DA for survivors with BRCA1/2 mutations following incorporation of the results of the focus group discussions (DA B)

	Topic	Content
Information	Introduction	Addressing the target group and target definition Notes on authors, funding source and use of the decision aid
	(1) Overview	Overview of the contents of this decision aid
	(2) What does a mutation in the BRCA1 or BRCA2 gene mean?	Function of the non-mutated BRCA genes Significance of hereditary BRCA mutations Risks of developing contralateral breast cancer and ovarian cancer (lifetime, age- and time-related risks) each subdivided into BRCA1 and BRCA2 mutations Personal risk of breast cancer (opposite side, affected side) Competing risks
	(3) Understanding your diagnosis and treatment of breast cancer	Information with regard to the affected breast Stages, types and spread of breast cancer Potential characteristics of breast cancer for women with BRCA1 and BRCA2 mutations Basic treatment steps: breast surgery, radiotherapy, medication Aftercare
	(4) What consequences can I expect based on the result of my genetic test?	Overview of potential preventive options Intensified breast cancer screening and aftercare programme: Aims, reliability, procedure, implementation, pros/cons, overview table Risk-reducing contralateral mastectomy (of the healthy opposite side): Effect on risk of developing breast cancer and survival Forms of mastectomy, pros/cons, overview table Forms of breast reconstruction, pros/cons, overview table Risk-reducing removal of both ovaries and Fallopian tubes: Effect on risk of developing ovarian cancer and survival, surgical procedure, options for relief of menopausal symptoms, pros/cons with overview table FAQs on other aspects
Support of decision-making	(5) How do I work out my own perspective? A guide to making an informed decision	Worksheet 1: Comparison of preventive options Worksheet 2: Significance of certain aspects in terms of your own cancer risk (clarifying values and preferences; box-ticking) Worksheet 3: A step-by-step guide to making your decision (your situation, clarifying values and preferences; free-form notes) Worksheet 4: Helping you prepare for your consultation with your doctor
	(6) Other helpful information	Points of contact for personal advice, self-help What can I do for myself? Tips for additional information material Glossary Contact addresses and links References
	(7) Appendix	Fact boxes for women with BRCA1- and BRCA2 mutations: Average risks of developing contralateral breast cancer: Lifetime, age and time-related risks Average risks of developing ovarian cancer: Lifetime, age and time-related risks

BRCA1 BReast CAncer gene 1, BRCA2 BReast CAncer gene 2, DA decision aid, FAQs frequently asked questions